Population
Eukaryotic cells / Arp2/3 complex
Design
Preclinical
Key result
Activation of the Arp2/3 complex likely involves engagement of two distinct sites on the complex by two VCA molecules, each delivering an actin monomer.
Authors
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No immediate clinical implications; extends Arp2/3 activation models but leaves open cardiac translation.
This study proposes a new model for Arp2/3 complex activation involving two VCA molecules binding to distinct sites.
Padrick et al. (2011) studied this question. Activation of the Arp2/3 complex likely involves engagement of two distinct sites on the complex by two VCA molecules, each delivering an actin monomer.