Key result
New combined risk score outperforms individual scores in predicting post-PCI MACCE with 0.71 AUC.
Why the study?
The study aimed to investigate the predictive value of the SYNTAX score, SYNTAX score II, and coronary artery calcium score on prognosis in patients after PCI.
Does a new combined risk score improve the prediction of MACCE compared to SYNTAX score, SYNTAX score II, and coronary artery calcium score in patients undergoing PCI?
Observational (n=195)
Does a new combined risk score improve the prediction of MACCE compared to SYNTAX score, SYNTAX score II, and coronary artery calcium score in patients undergoing PCI?
Effect estimate: AUC 0.711 (95% CI 0.606-0.816)
p-value: p=<0.01
A new combined risk score incorporating SYNTAX and coronary artery calcium scores may offer superior prognostic value for predicting MACCE in patients after PCI.
May support better post-PCI MACCE prediction; leaves open clinical utility pending prospective validation.
This study aims to investigate the predictive value of SYNTAX score,SYNTAX score II and coronary artery calcium score on the prognosis of patients after PCI. The SYNTAX score, SYNTAX score II and coronary artery calcium score were calculated. The primary end point was major adverse cardiac and cerebrovascular events (MACCE). 195 patients were included, 182 patients were followed up and the median follow-up time was 34.5 months. The MACCE occurred in 30 patients. The incidence of MACCE of lower risk, medium risk and high risk were: SYNTAX score: 6.7%, 18.3%, 24.2%; coronary artery calcium score: 9.7%, 18.3%, 21.7%; SYNTAX score II: 6.6%, 16.4%, 26.7%; new combined risk score: 7.7%, 8.1%, and 35.8%. ROC analysis showed that SYNTAX score (AUC: 0.641, 95%CI: 0.540-0.743), coronary artery calcium score (AUC: 0.597, 95%CI: 0.490 -0.704), SYNTAX score II (AUC: 0.662, 95%CI: 0.561 - 0.763), new combined risk score (0.711, 95%CI: 0.606 - 0.816). The new combined risk score tended to be superior compared to other risk score (p<0.01). The results suggested that SYNTAX score, SYNTAX score II and new combined risk score can predict the occurrence of MACCE after PCI, new combined risk score provides superior prediction.
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Rong et al. (2021) conducted an observational in Patients undergoing percutaneous coronary intervention (n=195). New combined risk score (SYNTAX score + coronary artery calcium score) vs. Individual risk scores (SYNTAX score, SYNTAX score II, coronary artery calcium score) was evaluated on Major adverse cardiac and cerebrovascular events (MACCE) (AUC 0.711, 95% CI 0.606-0.816, p=<0.01). A new combined risk score predicted major adverse cardiac and cerebrovascular events after PCI better than individual scores (AUC 0.711; 95% CI 0.606-0.816; p<0.01).
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