Key result
Serum cholesterol and insulin resistance correlated with diastolic blood pressure increases during exercise, which were greater in men with type 2 diabetes than controls (13.6 vs 2.7 mm Hg; P=0.002).
Why the study?
Do serum cholesterol and insulin resistance correlate with changes in diastolic blood pressure during mild exercise in men?
Population
75 healthy active men in the primary analysis, and an additional cohort of 10 men with uncomplicated type 2…
Comparison
Fixed low-workload bicycle ergometry vs Resting baseline values
Design
Cross-sectional
Authors
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Exercise BP rises may flag metabolic risk in men; leaves open whether cholesterol or insulin resistance drive exertional hypertension.
Cross-Sectional (n=95)
Do serum cholesterol and insulin resistance correlate with changes in diastolic blood pressure during mild exercise in men?
Absolute Event Rate: 13.6% vs 2.7%
p-value: p=0.002
Changes in diastolic blood pressure during mild exercise are strongly associated with total cholesterol and insulin resistance, which may contribute to the development of hypertensive complications in dyslipidemic or insulin-resistant patients.
Brett et al. (2000) conducted a cross-sectional in Healthy active men and type 2 diabetes (n=95). Serum cholesterol, insulin resistance, and type 2 diabetes vs. Nondiabetic controls (for the diabetes cohort) was evaluated on Change in diastolic blood pressure during exercise (p=0.002). Serum cholesterol and insulin resistance correlated with diastolic blood pressure increases during exercise, which were greater in men with type 2 diabetes than controls (13.6 vs 2.7 mm Hg; P=0.002).
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