Key result
Serum LD-1 activity at 200 U/L accurately identifies ~96% of AMI cases, outperforming the LD-1/LD ratio.
Why the study?
Does measurement of serum LD-1 activity accurately diagnose acute myocardial infarction in patients with suspected AMI?
Observational (n=331)
Does measurement of serum LD-1 activity accurately diagnose acute myocardial infarction in patients with suspected AMI?
Serum LD-1 activity is a highly reliable diagnostic marker for acute myocardial infarction when measured 24-72 hours after symptom onset, outperforming the LD-1/LD ratio.
No takes yet. Share an insight, caveat, or question.
May support LD-1 at 200 U/L for AMI diagnosis 24–72 h post-onset; leaves open prospective validation against current biomarkers.
Gerhardt et al. (1983) conducted an observational in Suspected acute myocardial infarction (AMI) (n=331). Serum lactate dehydrogenase (LD) isoenzyme 1 measurement vs. Serum LD-1/LD ratio was evaluated on Diagnostic verification and exclusion of AMI at a discriminatory level of 200 U/L. Serum LD-1 activity at a discriminatory level of 200 U/L verified the diagnosis in 96% of AMI cases and excluded it in 96% of non-AMI cases, proving more reliable than the LD-1/LD ratio.
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