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January 1, 1997Journal of the Chemical Society Perkin Transactions 1

Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group

Nicola K. Lembicz Sharon Grant W. Clegg Roger J. Griffin S.L. Heath Bernard T. Golding

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Abstract

Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding ‘DABCO-purines’ 1a–d, which undergo facile displacement reactions with alkoxides in dimethyl sulfoxide to afford 6-oxy-substituted purines.

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Lembicz et al. (1997) studied this question.

synapsesocial.com/papers/6aa2fc3d62ddfa3c6c4dc5b1 https://doi.org/10.1039/a608207f

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