Key result
Inactivated hepatitis A vaccine achieves 100% seroconversion in children with Down syndrome, matching healthy controls.
Why the study?
Does an inactivated hepatitis A vaccine provide adequate immunogenicity and safety in children with Down syndrome compared to healthy controls?
Population
127 children ages 1 to 12 years, including 63 noninstitutionalized children with Down syndrome and 64…
Comparison
Inactivated hepatitis A virus vaccine containing… vs Healthy control children receiving the same…
Design
Cohort, open
Follow-up
7 months
Authors
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May support hepatitis A vaccination in Down syndrome children; extends immunogenicity data but leaves open need for randomized confirmation.
Does an inactivated hepatitis A vaccine provide adequate immunogenicity and safety in children with Down syndrome compared to healthy controls?
Absolute Event Rate: 100% vs 100%
p-value: p=0.117
Inactivated hepatitis A vaccine is highly immunogenic and well tolerated in children with Down syndrome, with responses comparable to healthy children.
Ferreira et al. (2004) studied Down syndrome (n=127). Inactivated hepatitis A vaccine vs. Healthy control children was evaluated on Seroconversion rate at month 7 (p=0.117). Inactivated hepatitis A vaccine achieved a 100% seroconversion rate at 7 months in children with Down syndrome, with geometric mean titers comparable to healthy controls (P=0.117).
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