Why the study?
Does a formalin-inactivated hepatitis A vaccine prevent clinically apparent hepatitis A in healthy children?
Population
1037 healthy seronegative children 2 to 16 years of age in an Hasidic Jewish community in upstate New York
Comparison
One intramuscular injection of a highly… vs Placebo
Design
RCT, randomly assigned, double-blind, placebo-controlled
Follow-up
mean of 103 days
Authors
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Supports routine childhood immunization against hepatitis A; confirms high efficacy of formalin-inactivated vaccine in RCT.
Does a formalin-inactivated hepatitis A vaccine prevent clinically apparent hepatitis A in healthy children?
A single dose of formalin-inactivated hepatitis A vaccine is highly protective against clinically apparent hepatitis A in healthy children.
Werzberger et al. (1992) studied this question.
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