Key result
A two-dose inactivated hepatitis A vaccine induced long-term immune persistence, with 100% and 97.3% of subjects remaining seropositive at 15 years for the 0,6 and 0,12 month schedules, respectively.
Why the study?
Does a two-dose inactivated hepatitis A vaccine provide long-term antibody persistence at 15 years in healthy adults?
Population
313 healthy adults aged 17-40 years, naïve for hepatitis A virus
Design
Cohort
Follow-up
15 years
Authors
Loading...
15-year anti-HAV persistence observed; extends observational durability data but leaves open booster recommendations.
Does a two-dose inactivated hepatitis A vaccine provide long-term antibody persistence at 15 years in healthy adults?
Absolute Event Rate: 100% vs 97.3%
A two-dose inactivated hepatitis A vaccine induces an immune response that persists for at least 15 years in healthy adults, regardless of whether the second dose is given at 6 or 12 months.
Herck et al. (2011) studied Healthy adults naïve for hepatitis A virus (n=313). Inactivated hepatitis A vaccine (Havrix) vs. 1,440 ELISA units (El.U) at 0, 12 months was evaluated on Seropositivity for anti-HAV antibodies at 15 years. A two-dose inactivated hepatitis A vaccine induced long-term immune persistence, with 100% and 97.3% of subjects remaining seropositive at 15 years for the 0,6 and 0,12 month schedules, respectively.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: