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Catalyzing Henry: Chiral bisimidazoline 1–Cu(OTf)2, in the presence of N-methylmorpholine as a base, was discovered to efficiently catalyze the nitroaldol reaction in a highly syn- and enantioselective manner for a broad range of aldehydes, including aromatic, heteroaromatic, α,β-unsaturated, and aliphatic aldehydes (see scheme).
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Cheng et al. (2010) studied this question.
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