Key result
A 60-year-old woman developed a spontaneous spinal epidural hematoma after 10 months of clopidogrel therapy, highlighting a rare but critical hemorrhagic complication of antiplatelet agents.
Case Report (n=1)
No
Clopidogrel use may be associated with the rare but critical complication of spontaneous spinal epidural hematoma, requiring high clinical suspicion and urgent surgical intervention.
May warrant heightened suspicion for spinal hematoma in clopidogrel-treated patients; leaves open causal association beyond this case report.
The hemorrhagic side effects associated with the use of clopidogrel are within the acceptable range and occur mainly at skin or gastrointestinal sites. We report a case of spontaneous spinal epidural hematoma (SSEH) in a 60-yr-old woman who was treated with clopidogrel for frequent transient ischemic attacks. To our knowledge, this is the second reported case of clopidogrel-induced SSEH. The patient's symptoms and past history of clopidogrel use suggested the diagnosis and made the procedure proceed quickly to operate SSEH 9 hr after the onset of paraplegia. The outcome was excellent. Therefore, with the popularity of antiplatelet prescription, physicians should keep in mind and urgently treat this unusual but critical side effect.
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Sung et al. (2007) conducted a case report in Spontaneous spinal epidural hematoma (n=1). Clopidogrel was evaluated on Spontaneous spinal epidural hematoma. A 60-year-old woman developed a spontaneous spinal epidural hematoma after 10 months of clopidogrel therapy, highlighting a rare but critical hemorrhagic complication of antiplatelet agents.
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