Buccal Drug Delivery System: A Comprehensive Review

The buccal area of the oral cavity is an ideal target for administering the desired medicine, as it helps overcome the limitations of conventional drug administration. The occurrence of presystemic metabolism and drug depletion in the digestive tract can be avoided by administering the medicine orally. The buccal drug delivery system is an innovative technique of delivering drugs that offers several advantages, particularly in terms of oral administration. The duration of placing the medicinal formulations at the desired site could be prolonged. The structures directly come into contact with both the absorbing surface and the mucus membrane, thereby enhancing the therapeutic effects of the delivered medicine. In addition to its numerous benefits, the buccal drug delivery system has a few drawbacks. These include the fact that the buccal supply is limited to specific places and there is a significant risk of medicine loss due to the movement of saliva and swallowing. Furthermore, in the future, the sector of oral drug distribution will require secure and convenient substances that enhance the absorption of drugs across the buccal membrane.