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March 1, 1972Journal of HygieneOpen Access

Detection of Bordetella pertussis antibodiesin human sera by complement-fixation and immunofluorescence

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Key result

Complement-fixation and immunofluorescence tests demonstrate ~91% agreement in detecting Bordetella pertussis antibodies.

  • n=784

Why the study?

Are complement-fixation and immunofluorescence tests reliable for detecting Bordetella pertussis antibodies in human sera?

Population

Sera from 41 patients with whooping cough, 125 vaccinated persons, and 618 controls; 24 cases of whooping…

Design

Cross-sectional

Authors

CBC. M. Patricia BradstreetUniversité Libre de BruxellesATAgnes J. TannahillWestern InfirmaryJEJ M EdwardsUniversity College of the North

Discussion

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Overview

Supports complement-fixation as alternative to immunofluorescence for pertussis serology; leaves open prospective validation of diagnostic performance.

Study Design

Type

Observational (n=784)

Structured PICO

Are complement-fixation and immunofluorescence tests reliable for detecting Bordetella pertussis antibodies in human sera?

P
Population
784 individuals, including 41 with confirmed whooping cough, 125 vaccinated children, and 618 controls, assessed for Bordetella pertussis antibodies.
E
Exposure
Complement-fixation test (CFT) and immunofluorescence (IF) tests
O
Outcome
Detection of Bordetella pertussis antibodiessurrogate

Both complement-fixation and immunofluorescence tests appear reliable for detecting Bordetella pertussis antibodies formed during infection and after vaccination.

Limitations

  • Small number of sera tested
  • Incomplete series of specimens from individual vaccinated children
  • Lack of serial testing during late convalescence
  • small number of sera tested

Cite This Study

Bradstreet et al. (1972) conducted an observational in Whooping cough (Bordetella pertussis) (n=784). Complement-fixation test and immunofluorescence test was evaluated on Agreement between complement-fixation and immunofluorescence tests for detecting B. pertussis antibodies. Complement-fixation and immunofluorescence tests demonstrated 90.7% agreement in detecting Bordetella pertussis antibodies, reliably identifying antibodies formed during infection and after vaccination.

synapsesocial.com/papers/6aa3181a6e48096bb048f8aahttps://doi.org/10.1017/s0022172400022117
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Diagnosis of Whooping Cough: Comparison of Serological Tests with Isolation of Bordetella Pertussis1970 · 30 citations