Key result
Pre-existing chronic kidney disease (GFR <60) was associated with significantly worse 30-day all-cause mortality following TAVR compared to GFR ≥60 (OR 1.40; 95% CI 1.13-1.73).
Why the study?
Does pre-existing chronic kidney disease (GFR <60) worsen short- and long-term outcomes in patients undergoing TAVR?
Population
8,688 patients undergoing transcatheter aortic valve replacement pooled from 10 studies
Comparison
Pre-existing chronic kidney disease defined as… vs Glomerular filtration rate (GFR) ≥ 60
Design
Meta-analysis
Follow-up
30 days and 1 year
Authors
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CKD (GFR<60) warrants enhanced risk stratification and monitoring in TAVR candidates; extends meta-analytic evidence on renal impairment as a prognostic factor.
Systematic Review (n=8,688)
Yes
Does pre-existing chronic kidney disease (GFR <60) worsen short- and long-term outcomes in patients undergoing TAVR?
Odds Ratio: 1.4 (95% CI 1.13–1.73)
Pre-existing CKD (GFR <60) is a strong predictor of worse short- and long-term mortality and renal outcomes following TAVR.
Ifedili et al. (2017) conducted a systematic review in Transcatheter Aortic Valve Replacement (TAVR) (n=8,688). Pre-existing chronic kidney disease (GFR <60) vs. GFR ≥60 was evaluated on 30-day all-cause mortality (OR 1.40, 95% CI 1.13-1.73). Pre-existing chronic kidney disease (GFR <60) was associated with significantly worse 30-day all-cause mortality following TAVR compared to GFR ≥60 (OR 1.40; 95% CI 1.13-1.73).
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