Key result
Semotiadil fumarate demonstrated longer-lasting antianginal effects (at least 9 h) than diltiazem, nifedipine, and nisoldipine in a rat model, with intermediate selectivity for coronary arteries.
Population
Rat experimental angina model evoked by vasopressin and rat isolated perfused hearts
Comparison
Semotiadil fumarate vs Diltiazem, nifedipine, and nisoldipine
Design
Preclinical
Follow-up
9 hours
Authors
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Should not yet change practice; hypothesis-generating for longer-acting calcium antagonists in rat angina models.
Semotiadil fumarate is a novel calcium antagonist with longer-lasting antianginal effects and intermediate selectivity for coronary arteries and myocardium compared to existing agents in rat models.
Mori et al. (1995) studied Rat experimental angina. Semotiadil fumarate vs. Diltiazem, nifedipine, and nisoldipine was evaluated on Duration of inhibitory effects in experimental angina and selectivity for coronary arteries and myocardium. Semotiadil fumarate demonstrated longer-lasting antianginal effects (at least 9 h) than diltiazem, nifedipine, and nisoldipine in a rat model, with intermediate selectivity for coronary arteries.
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