A new and improved synthesis of 6‐aryl‐1,2,4‐triazolo[4,3‐b]pyridazines

A new and improved synthesis of 6‐aryl‐1,2,4‐triazolo[4,3‐b]pyridazines is described. This methodology provides the title compounds under mild conditions and in high yields. The first step comprises the condensation of an aryl methyl ketone with a 4‐amino‐1,2,4‐triazole in toluene heated at reflux. The second step involves the condensation of that imine and t‐butoxybis(dimethylamino)methane in tetrahydrofuran at ambient temperature. The third step constitutes the pyridazine ring closure to the title compounds in acetic acid heated at reflux.