A method for surface-selective laser sintering which produces mineral-polymeric materials based on calcium phosphates and aliphatic polyesters was developed. Three-dimensional matrices of the given architectonics for replacement of bone defects and bone tissue engineering were obtained. The microstructure of the experimental samples obtained and their surface morphology and internal structure were investigated by scanning electron microscopy (SEM). The characteristic values of the compressive strength and relative deformation of the mineral-polymer composite samples obtained by surface-selective laser sintering of fine powders consisting of 80 wt % ceramic granules based on tricalcium phosphate and 20 wt % D,L-polylactide PDL04 corresponded to the characteristic indices of the similar parameters for the trabecular bone tissue. As a result of the initial study of the biological properties of mineral-polymer composite scaffolds made by surface-selective laser sintering, it was shown that they had low cytotoxicity and no adverse effects on the proliferative potential of mesenchymal stem cells. The technology of surface-selective laser sintering suggested could be effectively used to create scaffolds for bone tissue engineering.
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Антонов et al. (2015) studied this question.
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