Key result
Ileal transposition increases plasma ANGPTL8 levels versus sham surgery in male rats on high-fat diets.
Why the study?
Metabolic surgery procedures target sustained weight loss and positive metabolic changes, prompting investigation into the relationship between ileal transposition, high-fat diet, and selected markers of lipid metabolism and inflammation.
Does ileal transposition alter plasma levels of ANGPTL8, PTX3, leptin, and adiponectin in rats fed a high-fat or control diet?
RCT (n=48)
randomly assigned
Does ileal transposition alter plasma levels of ANGPTL8, PTX3, leptin, and adiponectin in rats fed a high-fat or control diet?
p-value: p=0.0041
In a rat model, the effects of ileal transposition on metabolic and inflammatory markers are ambiguous and heavily modified by postoperative diet.
May indicate diet-specific metabolic responses to ileal transposition in rats; leaves open human translation and clinical relevance.
Background. Metabolic surgery procedures are designed not only for sustained weight loss but also for achieving positive metabolic changes, including improved glucose tolerance and insulin sensitivity, along with an increase in energy expenditure. Based on recent findings, the present study focuses on the relationship between the effects of ileal transposition (IT), high-fat diet (HFD), and selected markers of lipid metabolism and inflammation. Methods. Forty-eight male rats were divided into two groups: HFD and control diet (CD) fed rats. After eight weeks, animals in each group were randomly assigned to two types of surgery: IT and SHAM. Thereafter, fifty percent of the animals in the HFD and CD groups had their diets changed, while the remaining half maintained their presurgery diets. Eight weeks after surgery, plasma levels of ANGPTL8, PTX3, leptin, and adiponectin were assessed. Results. The IT group pre- and postoperatively maintained on the HFD showed higher ANGPTL8 level compared to SHAM operated animals ( p = 0.0041 ). The effect of IT on PTX3 level in the group pre- and postoperatively maintained on a CD was not significant, and there were no differences compared to SHAM. Only the postoperative diet change to HFD increased PTX3 level in the IT operated animals ( p = 0.0002 ). The IT group had increased plasma adiponectin ( p = 0.026 ) and leptin ( p = 0.0027 ) levels after dietary change to HFD compared to IT rats fed CD. Conclusions. This study indicates that the outcomes of metabolic surgery can be greatly modified by HFD. The effects of the IT procedure in this experiment are ambiguous and do not provide a clear answer as to whether or not they are beneficial.
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Sawczyn et al. (2021) reported an RCT. Ileal Transposition (IT) vs. SHAM surgery was evaluated on Plasma level of ANGPTL8 (p=0.0041). Ileal transposition in male rats maintained on a high-fat diet resulted in significantly higher plasma ANGPTL8 levels compared to SHAM surgery (p=0.0041).
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