Key result
Diabetes in patients undergoing off-pump coronary bypass surgery was associated with significantly longer early postoperative processes and increased nitric oxide levels compared to controls (p<0.05).
Why the study?
The main cause of atherosclerosis is disruption of trace element biobalance and endothelial damage accompanied by increased oxidative stress, motivating evaluation of these relations in patients undergoing off-pump coronary bypass surgery.
How does off-pump coronary artery bypass surgery affect trace elements, oxidative stress markers, and homocysteine levels in diabetic patients compared to controls?
Cohort
How does off-pump coronary artery bypass surgery affect trace elements, oxidative stress markers, and homocysteine levels in diabetic patients compared to controls?
p-value: p=<0.05
Off-pump coronary artery bypass surgery increases oxidative stress markers such as NO and MDA due to inflammatory stress, with diabetic patients experiencing longer hospital stays.
May prolong early recovery in diabetic off-pump CABG patients; hypothesis-generating for nitric oxide's perioperative role.
Background: The main cause of atherosclerosis is the disruption of trace element biobalance and endothelial damage accompanied by increased oxidative stress. Methods: In this clinical prospective study, all diabetic patients were randomly selected according to the Euroscore II risk classication. Offpump coronary bypass surgery was performed in all cases. From the blood samples taken before and after the surgery, zinc and copper, malondialdehyde lipid peroxidase (MDA), superoxide dismutase (SOD), total oxidant/antioxidant capacity (TOS/TAC), nitric oxide (NO), HbA1c and homocysteine levels were analyzed. Results:Early postoperative processes were signicantly longer in the diabetic group. Trace elements did not change after surgery. TOS, NO, and SOD activities were signicantly increased in all groups compared with the control group. NO levels signicantly increased in the T1DM group compared with the control group. (p <0.05). There was a positive correlation between HbA1c and homocysteine, especially in T1DM (p <0.05). Conclusion: Zn/Cu and SOD levels were not affected by the operation in patients from the same risk group, and the hospital stay was longer in the diabetic group. NO, and MDA levels increased after surgery due to inammatory stress, but homocysteine levels did not change except in cases requiring a long hospital stay.
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Bozkaya et al. (2022) conducted a cohort in Diabetes in patients undergoing off-pump coronary artery bypass surgery. Diabetes vs. Control group was evaluated on Early postoperative processes duration and oxidative stress markers (p=<0.05). Diabetes in patients undergoing off-pump coronary bypass surgery was associated with significantly longer early postoperative processes and increased nitric oxide levels compared to controls (p<0.05).
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