Key result
Allogeneic kidney transplantation preserves long-term normotensive blood pressure and circadian patterns in ~83% of rats.
Blood pressure and its 24-h circadian pattern are preserved after successful allogeneic kidney transplantation in a rat model of chronic rejection.
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Preserved BP in rat allografts warrants mechanistic studies; leaves open clinical relevance in human transplantation.
We investigated long-term and circadian blood-pressure changes in a Fischer → Lewis rat model of chronic renal allograft rejection. Ten days after allogeneic kidney transplantation, rats were equipped with telemetry transmitters for continuous monitoring of blood pressure. Urine was sampled 24, 96 and 180 days after kidney transplantation for measurement of renal protein loss and excretion of nitric oxide metabolities. Proteinuria increased with time after transplantation, while urinary excretion of nitric oxide metabolites declined. In five of six rats blood pressure remained in the normotensive range, and its 24-h pattern was preserved up to 6 months post-transplantation. One animal showed hypertensive blood pressure and a disturbed 24-h pattern with peak values during the rest period. In the post-mortem analysis this rat showed a hydronephrotic kidney graft. In conclusion, blood pressure and its 24-h pattern are preserved after successful allogeneic kidney transplantation in the rat.
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Witte et al. (2003) studied Chronic renal allograft rejection (rat model) (n=6). Allogeneic kidney transplantation was evaluated on Blood pressure and its 24-h pattern. Blood pressure and its 24-h pattern were preserved in the normotensive range up to 6 months after successful allogeneic kidney transplantation in 5 of 6 rats.
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