Key result
Lower eGFR is linked to greater LV wall thickness and ~91% more fibrosis.
Why the study?
Cardiac remodeling develops with progression of kidney disease, but few studies have examined cardiac pathology across a range of eGFRs.
Is reduced eGFR associated with increased left ventricular wall thickness, cardiac cell size, and myocardial fibrosis in patients without prior heart disease?
Cross-Sectional (n=334)
Is reduced eGFR associated with increased left ventricular wall thickness, cardiac cell size, and myocardial fibrosis in patients without prior heart disease?
p-value: p=<0.05
Reduced eGFR is independently associated with adverse cardiac remodeling, including left ventricular hypertrophy, cellular enlargement, and myocardial fibrosis, even in patients without prior diagnosed heart disease.
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Supports adverse LV remodeling in advanced CKD without known heart disease; hypothesis-generating for causality, needs longitudinal confirmation.
Izumaru et al. (2019) conducted a cross-sectional in Reduced estimated glomerular filtration rate (n=334). Reduced estimated glomerular filtration rate (eGFR) vs. Higher eGFR (≥60 mL/min/1.73m2) was evaluated on Thickness of the left ventricular wall, sizes of cardiac cells, and percentages of fibrosis (p=<0.05). Lower eGFR (<30 vs ≥60 mL/min/1.73m2) was associated with greater left ventricular wall thickness (10.3 vs 9.1 mm, P<0.05) and higher fibrosis percentage (6.14% vs 3.22%, P<0.001).
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