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November 1, 1945Journal of Clinical InvestigationOpen Access

The Estimation of Hepatic Blood Flow in Man

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Authors

SBS. E. BradleyBoston UniversityFIFranz J. IngelfingerUnited States Army Medical CommandGBGeraldine P. BradleyBoston University

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Implication

Physiological evaluation demonstrates techniques to measure hepatic blood flow in humans, highlighting ways to distinguish cellular changes from hemodynamics.

Key Points

  • To develop and evaluate an accurate method for measuring hepatic blood flow in humans to support the quantitative analysis of liver function.
  • Assessed methodologies for quantifying hepatic circulation to differentiate hemodynamic effects from altered cellular activity.
  • Evaluated physiological direct-measurement techniques previously devised for measuring blood flow through the liver.
  • Determining hepatic blood flow enables the accurate evaluation of metabolic exchanges across liver tissue.
  • Direct measurement allows clinical differentiation between functional changes caused by systemic hemodynamics and intrinsic cellular dysfunction.

Cite This Study

Bradley et al. (1945) studied this question.

synapsesocial.com/papers/6aa3779aa45983801221c850https://doi.org/10.1172/jci101676
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