Key result
NIDDM patients show no reduction in basal plasma nitrite/nitrate levels compared to normal controls.
Why the study?
Are basal plasma nitrite/nitrate levels reduced in patients with noninsulin-dependent diabetes mellitus compared to normal controls?
Population
15 patients with noninsulin-dependent diabetes mellitus and 13 normal controls (n=28)
Design
Case-control
Authors
Loading...
Preserved basal NO production in NIDDM does not implicate synthesis defects; leaves open superoxide inactivation as contributor to vascular dysfunction.
Case-Control (n=28)
Are basal plasma nitrite/nitrate levels reduced in patients with noninsulin-dependent diabetes mellitus compared to normal controls?
Absolute Event Rate: 37.3% vs 29.4%
Basal nitric oxide production is not impaired in patients with noninsulin-dependent diabetes mellitus, suggesting that vascular dysfunction may result from reduced NO bioavailability rather than decreased synthesis.
Catalano et al. (1997) conducted a case-control in Noninsulin-dependent diabetes mellitus (n=28). Noninsulin-dependent diabetes mellitus vs. Normal controls was evaluated on Plasma nitrite/nitrate levels in basal conditions. Basal plasma nitrite/nitrate levels were not reduced in patients with noninsulin-dependent diabetes mellitus compared to normal controls (37.3 ± 14.7 vs 29.4 ± 8.6 μmol/l).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: