Key result
Postoperative VTE occurred in 0.899% of patients within 30 days after gynecologic cancer surgery, with abdominal surgery (1.56% vs 0.6% for MIS) identified as a significant risk factor.
Why the study?
The incidence, timing, and risk factors of venous thromboembolism after surgery for gynecological cancer, as well as its effects on survival, needed description.
What are the incidence, timing, and risk factors for venous thromboembolism after surgery for gynecologic cancer?
Observational (n=4,005)
No
What are the incidence, timing, and risk factors for venous thromboembolism after surgery for gynecologic cancer?
Absolute Event Rate: 1.56% vs 0.6%
The second week after surgery is a high-risk period for VTE in gynecological cancer patients, with abdominal surgery, blood transfusion, and ovarian/fallopian tube cancer being significant risk factors.
May inform selective VTE prophylaxis in high-risk gynecologic cancer patients; leaves open optimal strategies for prospective validation.
Objective: To describe the incidence, timing, and risk factors of venous thromboembolism (VTE) after surgery for gynecological cancer and to evaluate its effects of these events on survival. Methods: This was a retrospective analysis from January 2008 through December 2016 at a single center. Data were recorded on surgical procedures, patient demographic characteristics, type of malignancy and VTE, and mortality outcomes within 30 days after surgery. Significant variables related to VTE were evaluated using bivariate analysis, and Logistic regression models were used to assess risk factors for VTE. Results: The overall rate of postoperative VTE was 0.899% (36/4005) within 30 days after surgery. Of these rates, the rate in abdominal surgery was 1.56% (19/1220), and the rate in minimally invasive surgery (MIS) was 0.6% (17/2785). The median time from surgery to diagnosis was 8.5 days. In univariate analysis, VTE was statistically significantly associated with ovarian and fallopian cancer (P < 0.05), older age (P = 0.001), and blood transfusion (P < 0.001). A multivariate logistic regression model was used to adjust for variables with P < 0.2 in univariate analysis and found that except for age, the other variables continued to have a significant association with VTE. Conclusion: The second week after surgery might be high-risk period of VTE occuring, and ovarian and fallopian tube cancer, abdominal surgery, and blood transfusion might be significant risk factors for developing VTE.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2021) conducted an observational in Gynecologic cancer (n=4,005). Abdominal surgery vs. Minimally invasive surgery (MIS) was evaluated on Postoperative VTE within 30 days after surgery. Postoperative VTE occurred in 0.899% of patients within 30 days after gynecologic cancer surgery, with abdominal surgery (1.56% vs 0.6% for MIS) identified as a significant risk factor.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: