Key result
ECMO explantation linked to triggering a pheochromocytoma crisis.
Pheochromocytoma crisis should be considered in unexplained shock or Takotsubo cardiomyopathy, and ECMO explantation in these patients requires close monitoring for rapid blood pressure fluctuations.
May precipitate pheochromocytoma crisis at ECMO explantation; hypothesis-generating observation requiring prospective validation.
Context: We report a 59 year old Chinese woman in pheochromocytoma multisystem crisis and was initially stabilised with ECMO; subsequently she manifested rapid cyclical fluctuation of blood pressure precipitated by explantation of ECMO. Case Description: Madam L presented with chest pain and giddiness. She developed cardiogenic shock refractory to double inotropes and intra-aortic balloon pump (IABP); but responded to ExtraCorporal Membrane Oxygenation (ECMO). Subsequently rapid cyclical blood pressure fluctuations from 230 mmHg to 50mmHg systolic occurred after explantation of ECMO. Biochemically urine metanephrines and normetanephrines were more than seven times above upper limit of normal. Imaging confirmed the presence of right adrenal mass likely pheochromocytoma. She was started on alpha blockade and underwent an uneventful laparotomy with removal of a 10 cm adrenal mass. Histology confirmed a large cystic pheochromocytoma with haemorrhagic components. Conclusions: Pheochromocytoma crisis should be suspected in cases of unexplained shock or Takutsubo cardiomyopathy; early recognition and ECMO support can be life-saving. In addition, ECMO explantation can trigger rapid cyclical blood pressure fluctuations and should be closely monitored for.
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Meifen et al. (2015) studied this question. Extra-corporal membrane oxygenation explantation was identified as a trigger for a pheochromocytoma crisis.
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