Key result
Engineering skeletal muscle using the C2C12 cell line in fibrin with genipin allowed tissues to form in 10.4 days and remain fully functional for up to 10 weeks.
Optimizing fibrin scaffolds with aprotinin and genipin allows for rapid and reliable engineering of functional skeletal muscle tissue from C2C12 cells for long-term in vitro studies.
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Supports extended in vitro muscle models; leaves open translation to cardiovascular applications pending in vivo validation.
Khodabukus et al. (2009) studied Skeletal muscle engineering. Fibrin scaffold with aprotinin or genipin was evaluated on Time in culture and force production. Engineering skeletal muscle using the C2C12 cell line in fibrin with genipin allowed tissues to form in 10.4 days and remain fully functional for up to 10 weeks.
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