What question did this study set out to answer?

To evaluate how the particle size and dissolution rate of aspirin formulations influence the extent of drug-induced gastrointestinal bleeding.

May 1, 1967Clinical Pharmacology & Therapeutics

The role of dosage form in aspirin‐induced gastrointestinal bleeding

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Authors

JLJack R. LeonardsUniversity School GLGerhard LevyUniversity of Florida

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Implication

Controlled trial finds increased gastrointestinal bleeding from aspirin regardless of particle size in healthy adults, suggesting dissolution rate does not alter blood loss.

Key Points

To evaluate how the particle size and dissolution rate of aspirin formulations influence the extent of drug-induced gastrointestinal bleeding.
Enrolled 12 healthy adult subjects to compare blood loss across different regimens.
Administered tablets formulated with fine aspirin particles, coarse aspirin particles, or placebo, alongside control periods with no tablets.
Fine-particle aspirin tablets dissolved and were absorbed from the gastrointestinal tract significantly faster than coarse-particle formulations.
Aspirin administration produced significantly greater gastrointestinal bleeding compared to unmedicated control periods, whereas placebo tablets caused no bleeding.
Differences in gastrointestinal blood loss between fine-particle and coarse-particle aspirin tablets were not statistically significant.

Cite This Study

Leonards et al. (1967) studied this question.

synapsesocial.com/papers/6aa393df5b75cc9dd9c96e54 https://doi.org/10.1002/cpt196783400

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Implication

Controlled trial finds increased gastrointestinal bleeding from aspirin regardless of particle size in healthy adults, suggesting dissolution rate does not alter blood loss.

The role of dosage form in aspirin‐induced gastrointestinal bleeding

Discussion

Member takes

Implication

Key Points

Cite This Study

The role of dosage form in aspirin‐induced gastrointestinal bleeding

Discussion

Member takes

Implication

Key Points

Cite This Study

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