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July 1, 1969Clinical Pharmacology & Therapeutics

Reduction or prevention of aspirin‐induced occult gastrointestinal blood loss in man

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Why the study?

Does aspirin in buffered solutions reduce occult gastrointestinal blood loss compared to conventional aspirin tablets in healthy subjects?

Population

n=57 healthy subjects

Comparison

Aspirin in buffered solutions at 2.6 or 3.9 Gm… vs Aspirin in conventional tablets at 2.6 or 3.9 Gm…

Design

Other

Follow-up

8-day periods

Authors

JLJack R. LeonardsUniversity SchoolGLGerhard LevyUniversity of Florida

Discussion

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Implication

Buffered aspirin solutions may limit occult GI blood loss; leaves open clinical relevance and generalizability beyond healthy subjects.

Structured PICO

Does aspirin in buffered solutions reduce occult gastrointestinal blood loss compared to conventional aspirin tablets in healthy subjects?

P
Population
n=57 healthy subjects
I
Intervention
Aspirin in buffered solutions (calcium-aspirin with low buffer capacity, calcium-sodium-aspirin with medium buffer capacity, or highly buffered sodium-aspirin with or without acetaminophen and caffeine) at 2.6 or 3.9 Gm daily for 8-day periods
C
Comparator
Aspirin in conventional tablets at 2.6 or 3.9 Gm daily for 8-day periods, and drug-free control periods
O
Outcome
Occult gastrointestinal blood loss in feces determined by the Cr51 methodsafety

Administering aspirin in highly buffered solutions prevents occult gastrointestinal blood loss compared to conventional tablets, suggesting the bleeding is a local rather than systemic effect.

Cite This Study

Leonards et al. (1969) studied this question.

synapsesocial.com/papers/6a9651c70f79e4f014b2e24bhttps://doi.org/10.1002/cpt1969104571
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastrointestinal Blood Loss during Prolonged Aspirin Administration1973 · 66 citations
  2. 2The role of dosage form in aspirin‐induced gastrointestinal bleeding1967 · 42 citations
  3. 3Human gastric mucosal bleeding induced by low dose aspirin, but not warfarin.1989 · 89 citations
  4. 4Incidence of gastrointestinal bleeding in patients with cardiovascular disease: buffered aspirin versus enteric-coated aspirin2011 · 31 citations
  5. 5Review article: gastrointestinal bleeding with low‐dose aspirin – what's the risk?2006 · 130 citations