Key result
Receptors for atrial natriuretic peptide were localized in the alveoli and bronchiolar smooth muscle cells of bovine lung and in podocytes of the kidney using specific antisera.
This study identifies the specific localization of ANP receptors in bovine lung and kidney tissues, providing foundational knowledge for understanding the pulmonary and renal actions of ANP.
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ANP receptor sites in bovine lung and kidney support targeted physiologic studies; should not yet change clinical practice.
Receptors for atrial natriuretic peptide (ANP) were localized in the alveoli and bronchiolar smooth muscle cells of bovine lung and in podocytes of the kidney by immunofluorescence and immunoperoxidase methods. Two specific antisera were raised against the ANP receptor purified from bovine lung plasma membranes: anti-Rc 140 and anti-Rc 70. Anti-Rc 140 was raised against the 140 KD native receptor having a homodimeric structure, and anti-Rc 70 was elicited by immunizing a rabbit with the 70 KD reduced subunits. Essentially identical staining patterns were obtained with both antisera. Identification of ANP receptor sites would provide useful information in understanding the pulmonary and renal actions of ANP.
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Kawaguchi et al. (1989) studied this question. Immunofluorescence and immunoperoxidase methods was evaluated on Localization of ANP receptors. Receptors for atrial natriuretic peptide were localized in the alveoli and bronchiolar smooth muscle cells of bovine lung and in podocytes of the kidney using specific antisera.
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