Key result
Immunohistochemical staining using a specific antiserum revealed intense localization of atrial natriuretic peptide (ANP) receptors in the glomeruli of bovine kidneys.
This study successfully localized ANP receptors to the glomeruli of bovine kidneys using a specific antiserum, supporting the physiological role of ANP in glomerular function.
Answers are grounded in this paper and cite their sources.
Reinforces ANP glomerular action models in bovine kidney; extends autoradiographic data but leaves open human translation.
Atrial natriuretic peptide (ANP) receptor was purified from the bovine lung by affinity chromatography and preparative gel electrophoresis. A specific antiserum was raised against the purified receptor and used to localize receptors immunohistochemically on bovine kidney sections. Intense staining was seen in glomeruli. This distribution corresponds to that of ANP binding sites revealed by previous autoradiographic analyses and matches a glomerular action of ANP suggested by physiological studies.
No takes yet. Share an insight, caveat, or question.
Shimonaka et al. (1987) studied this question. Specific antiserum against purified ANP receptor was evaluated on Immunohistochemical localization of ANP receptors. Immunohistochemical staining using a specific antiserum revealed intense localization of atrial natriuretic peptide (ANP) receptors in the glomeruli of bovine kidneys.
Synapse has enriched 10 related papers. Consider them for comparative context: