Autoradiographic discrimination of brain and atrial natriuretic peptide-binding sites in the rat kidney.
Population
Rat kidney model
Comparison
125I porcine BNP1-26 and 125I rat alpha-ANP1-28 vs Competitive inhibition with C-ANP4-23
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for renal natriuretic peptide signaling in rodents; leaves open translation to human physiology or therapy.
Structured PICO
P
Population
Rat kidney model
I
Intervention
125I porcine BNP1-26 (pBNP1-26) and 125I rat alpha-ANP1-28 (rANP1-28)
C
Comparator
Competitive inhibition with C-ANP4-23
O
Outcome
Regional distribution of receptor subpopulations and competitive inhibition of binding sitessurrogate
The study demonstrates that BNP and ANP compete for the same binding sites in the rat kidney, with distinct regional distributions of clearance and nonclearance receptors, suggesting a role for renal nerve-derived BNP in renal function.
Cite This Study
Rutherford et al. (1991) studied this question.