July 1, 1990AJP Renal Physiology
Autoradiographic localization of atrial natriuretic peptide receptor subtypes in rat kidney
Key result
In rat kidneys, ANP clearance receptors are restricted to the glomeruli and renal arterial system, with C-ANP inhibiting greater than 60% of glomerular binding.
Population
Rat kidney tissue
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Localizes ANP clearance receptors to rat glomeruli and arteries; leaves open human translation and therapeutic targeting.
Structured PICO
P
Population
Rat kidney tissue
I
Intervention
In vitro autoradiography using des[Gln18,Ser19,Gly20,Leu21,Gly22]-ANP-(4-23) (C-ANP) and 125I-Tyr0-ANP-(5-25)
O
Outcome
Distribution and binding characteristics of atrial natriuretic peptide (ANP) clearance receptorssurrogate
This preclinical study demonstrates that ANP clearance receptors in the rat kidney are localized specifically to the glomeruli and renal arterial system.
Cite This Study
Brown et al. (1990) studied this question. C-ANP and 125I-Tyr0-ANP-(5-25) was evaluated on Localization and binding affinity of ANP clearance receptors. In rat kidneys, ANP clearance receptors are restricted to the glomeruli and renal arterial system, with C-ANP inhibiting greater than 60% of glomerular binding.