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July 1, 1992AJP Renal Physiology

Renal receptors for atrial and C-type natriuretic peptides in the rat

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Population

Kidneys from adult Wistar rats

Design

Preclinical

Authors

JBJohn C. BrownMedical Council of CanadaZZZhiyi ZuoUniversity of Virginia

Discussion

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Implication

Supports distinct ANP/CNP receptor mapping in rat kidney; leaves open human cardiorenal translation.

Structured PICO

P
Population
Kidneys from adult Wistar rats
I
Intervention
In vitro autoradiography with 125I-labeled alpha-ANP and 125I-[Tyr0]CNP-(1-22)
O
Outcome
Receptor binding characteristics (Kd, Ki) and localization in the kidneysurrogate

This preclinical study demonstrates distinct localization and binding affinities of alpha-ANP and CNP receptors in the rat kidney, with CNP binding solely to glomeruli.

Cite This Study

Brown et al. (1992) studied this question.

synapsesocial.com/papers/6a85467eff13e6e4e743ddf0https://doi.org/10.1152/ajprenal.1992.263.1.f89
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Receptor proteins and biological effects of C-type natriuretic peptides in the renal glomerulus of the rat1994 · 17 citations
  2. 2Autoradiographic localization of atrial natriuretic peptide receptor subtypes in rat kidney1990 · 20 citations
  3. 3Rat renal preglomerular vessels, glomeruli and papillae do not express detectable quantities of B-type natriuretic peptide receptor1994 · 11 citations
  4. 4C-type natriuretic peptide and atrial natriuretic peptide receptors of rat brain1993 · 40 citations
  5. 5Identification of renal natriuretic peptide receptor subpopulations by use of the non‐peptide antagonist, HS‐142‐11994 · 11 citations