Key result
ANP-B receptors are virtually undetectable across rat renal preglomerular vessels, glomeruli, and papillae.
Why the study?
The expression of B-type natriuretic peptide (ANP-B) receptors in rat renal preglomerular vessels, glomeruli, and papillae was uncertain.
Population
Rat renal isolated tissues: preglomerular vessels, glomeruli and papillae
Comparison
Radioligand binding of [125I]-ANF, C-ANF, CNP, and [125I]-[Tyr]CNP(1-22)
Design
Radioligand receptor quantitation study
Authors
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Receptor subtype mapping in rat renal tissues may guide further studies; leaves open clinical translation in hypertension.
This preclinical study demonstrates that ANP-B receptors are not detectably expressed in rat renal preglomerular vessels, glomeruli, or papillae.
León et al. (1994) studied this question. Radioligand binding assays was evaluated on ANP-B receptor expression. Radioligand binding studies suggest that ANP-B receptors are either absent or present in undetectable amounts in rat renal preglomerular vessels, glomeruli, and papillae.
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