Key result
Spontaneously hypertensive rats showed higher affinities but lower maximum binding capacities for alpha-ANP in their outer cortical glomeruli and medullas compared to Wistar-Kyoto rats.
The study demonstrates that renal ANP receptor subtypes differ in binding affinity and capacity between spontaneously hypertensive and normotensive rats.
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Altered ANP binding in hypertensive rat kidneys is hypothesis-generating; leaves open human relevance and precludes practice changes.
Brown et al. (1990) studied Hypertension (Spontaneously hypertensive rats). Spontaneously hypertensive rats (SHR) vs. Wistar-Kyoto (WKY) rats was evaluated on Renal atrial natriuretic peptide receptor subtypes binding characteristics. Spontaneously hypertensive rats showed higher affinities but lower maximum binding capacities for alpha-ANP in their outer cortical glomeruli and medullas compared to Wistar-Kyoto rats.
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