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February 1, 1986AJP Renal Physiology

Localization of binding sites for alpha-rat atrial natriuretic polypeptide in rat kidney

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Population

Rat kidney

Design

Preclinical

Authors

CKChizuko KosekiTagCyx Biotechnologies (Japan)YHYoshitaka HayashiNagoya UniversitySTShozo TorikaiHokkaido University

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Overview

Maps alpha-rANP receptors to rat glomeruli and tubules; hypothesis-generating for ANP actions without clinical translation.

Structured PICO

P
Population
Rat kidney
I
Intervention
125I-labeled alpha-rat ANP (alpha-rANP) autoradiography and binding assay
O
Outcome
Intrarenal localization of receptors for atrial natriuretic polypeptide (ANP)surrogate

Alpha-rat ANP receptors are localized primarily in the glomeruli, inner medullary collecting tubules, and renal artery of the rat kidney, suggesting physiological actions at these sites.

Cite This Study

Koseki et al. (1986) studied this question.

synapsesocial.com/papers/6a7757caa0847c3df1ec70c8https://doi.org/10.1152/ajprenal.1986.250.2.f210
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of atrial natriuretic peptide binding sites within the rat kidney1986 · 64 citations
  2. 2Intrarenal Localization of Receptors for α-Rat Atrial Natriuretic Polypeptide: An Autoradiographic Study with [125I]-Labeled Ligand Injected in Vivo into the Rat Aorta1986 · 14 citations
  3. 3In vitro autoradiographic localization of ANP receptors in rat kidney and adrenal gland1986 · 81 citations
  4. 4Autoradiographic localization of atrial natriuretic peptide receptor subtypes in rat kidney1990 · 20 citations
  5. 5Autoradiographic localization of binding sites for atrial natriuretic factor1985 · 58 citations