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November 1, 1985Canadian Journal of Physiology and Pharmacology

Autoradiographic localization of binding sites for atrial natriuretic factor

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Population

Wistar rat tissues, spontaneously hypertensive rats, guinea pig, and rabbit tissues

Comparison

Incubation of tissue sections with 125I-labelled… vs None

Design

Preclinical

Authors

HSHerbert P. von SchroederUniversity of TorontoENErica NishimuraNovo Nordisk (Denmark)CMC. H. S. McIntoshUniversity Health Network

Discussion

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Implication

ANF binding distributions in rats may prompt human receptor studies; leaves open hypertension-specific alterations.

Structured PICO

P
Population
Wistar rat tissues, spontaneously hypertensive rats, guinea pig, and rabbit tissues
I
Intervention
Incubation of tissue sections with 125I-labelled atrial natriuretic factor (ANF)
C
Comparator
None (comparison between spontaneously hypertensive rats and Wistar rats)
O
Outcome
Localization and density of ANF binding sitessurrogate

This preclinical study maps the distribution of atrial natriuretic factor binding sites across various tissues and species, highlighting its potential systemic regulatory roles.

Cite This Study

Schroeder et al. (1985) studied this question.

synapsesocial.com/papers/6a70c6bcf44fa9f079de797dhttps://doi.org/10.1139/y85-226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human.1986 · 85 citations
  2. 2Localization of atrial natriuretic peptide binding sites within the rat kidney1986 · 64 citations
  3. 3Localization of binding sites for alpha-rat atrial natriuretic polypeptide in rat kidney1986 · 83 citations
  4. 4Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: Autoradiographic localization and fluid balance dependent changes1986 · 58 citations
  5. 5In vitro autoradiographic localization of ANP receptors in rat kidney and adrenal gland1986 · 81 citations