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May 1, 1986Proceedings of the National Academy of SciencesOpen Access

Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: Autoradiographic localization and fluid balance dependent changes

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Population

Rats (including normal, water-deprived, salt-loaded with 2.0% NaCl, and diabetic models)

Comparison

Fluid balance alterations vs Normal fluid balance/control rats

Design

Preclinical

Follow-up

Up to 72 hours

Authors

DLDavid R. LynchChildren's Hospital of PhiladelphiaKBKaren M. BraasUniversity of VermontSSS H SnyderJohns Hopkins University

Discussion

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Implication

Supports coordinated volume regulation in animals; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Rats (including normal, water-deprived, salt-loaded with 2.0% NaCl, and diabetic models)
I
Intervention
Fluid balance alterations (water deprivation, 2.0% NaCl drinking water, diabetes)
C
Comparator
Normal fluid balance/control rats
O
Outcome
Localization and number of high-affinity ANF binding sitessurrogate

ANF receptors in the kidney, adrenal gland, and brain dynamically respond to fluid balance changes, suggesting a coordinated role in volume regulation.

Cite This Study

Lynch et al. (1986) studied this question.

synapsesocial.com/papers/6a7757caa0847c3df1ec70c7https://doi.org/10.1073/pnas.83.10.3557

Topics

Hypertension management
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Also Consider

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  1. 1Renal mechanism of action of rat atrial natriuretic factor.1985 · 247 citations
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  3. 3The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA Clone1984 · 232 citations
  4. 4The Circumventricular Organs and the Central Actions of Angiotensin2008 · 324 citations