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August 1, 1986Hypertension

Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human.

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Population

Peripheral tissues (including postmortem kidneys) from guinea pigs, rats, and humans

Design

Preclinical

Authors

CMChristopher R. MantyhDuke UniversityLKLawrence KrugerSemmelweis UniversityNBNicholas C. BrechaUniversity of California, Los Angeles

Discussion

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Implication

Supports animal models for ANF hypertension research; leaves open clinical translation pending human data.

Structured PICO

P
Population
Peripheral tissues (including postmortem kidneys) from guinea pigs, rats, and humans
I
Intervention
Autoradiographic localization of atrial natriuretic factor (ANF) binding sites
O
Outcome
Localization and concentration of ANF binding sites in peripheral tissuessurrogate

The conserved localization of ANF binding sites in the kidneys across species supports the use of animal models to study ANF's role in human fluid regulation, hypertension, and heart failure.

Cite This Study

Mantyh et al. (1986) studied this question.

synapsesocial.com/papers/6a7e4b4e971946435f4f9b30https://doi.org/10.1161/01.hyp.8.8.712
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthetic Atrial Natriuretic Factor Induces Release (Possibly Receptor-Mediated) of Vasopressin from Rat Posterior Pituitary1985 · 53 citations
  2. 2Evidence for the Existence of Atrial Natriuretic Factor-Containing Neurons in the Rat Brain2008 · 226 citations
  3. 3Bioactive Cardiac Substances: Potent Vasorelaxant Activity in Mammalian Atria1983 · 711 citations
  4. 4Cardiac Atria of BIO 14.6 Hamsters Are Deficient in Natriuretic Factor1984 · 97 citations