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Atrial natriuretic factor specific binding sites were localized exclusively in the interstitial cells of the rat testis, suggesting a physiologic role for ANF in testicular functions.
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ANF receptors are localized specifically in the interstitial cells of the rat testis, suggesting a physiologic role for ANF in testicular functions.
Recent data have suggested that atrial natriuretic factors (ANFs) can modulate Leydig cell functions. An in vitro radioautographic procedure on slide-mounted frozen testicular sections was used to localize ANF receptors in rat testis. The radioligand was rat [125I]ANF-28. It was demonstrated that ANF specific binding sites were present only in interstitial cells, and that the other testicular compartments were not significantly labeled. These results suggest that ANF could have some physiologic role in testicular functions.
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Georges Pelletier (1988) studied this question. In vitro radioautographic procedure using rat [125I]ANF-28 was evaluated on Localization of ANF receptors in rat testis. Atrial natriuretic factor specific binding sites were localized exclusively in the interstitial cells of the rat testis, suggesting a physiologic role for ANF in testicular functions.
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