Key result
Injection of 125I-atrial natriuretic factor localized binding sites in circumventricular organs and cerebral vasculature, which was reduced by 70-90% with excess unlabeled hormone.
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Animal autoradiography identifies ANF binding in brain; leaves open human physiological roles and therapeutic relevance.
Bianchi et al. (2008) studied this question. 125I-Arg 101-Tyr 126 atrial natriuretic factor vs. 125I-atrial natriuretic factor plus an excess of unlabeled hormone was evaluated on Localization of radioautographic reaction. Injection of 125I-atrial natriuretic factor localized binding sites in circumventricular organs and cerebral vasculature, which was reduced by 70-90% with excess unlabeled hormone.
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