What question did this study set out to answer?

Determine the intrarenal distribution and specific cellular binding sites of alpha-rat atrial natriuretic polypeptide (alpha-rANP) receptors under in vivo conditions.

January 1, 1986The Japanese Journal of PharmacologyOpen Access

Intrarenal Localization of Receptors for α-Rat Atrial Natriuretic Polypeptide: An Autoradiographic Study with 125I-Labeled Ligand Injected in Vivo into the Rat Aorta

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Authors

CKChizuko KosekiTagCyx Biotechnologies (Japan)YKYasushi KanaiTohoku University YHYujiro HayashiOsaka Prefectural Medical Center

Discussion

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Overview

Refines rodent ANP receptor maps; extends prior localization data but leaves open human relevance.

Key Points

Determine the intrarenal distribution and specific cellular binding sites of alpha-rat atrial natriuretic polypeptide (alpha-rANP) receptors under in vivo conditions.
Injected [125I]-labeled alpha-rANP into the aorta of living rats under physiological conditions.
Mapped intrarenal binding sites using light microscopic and electron microscopic autoradiography across cortical and medullary structures.
Demonstrated prominent receptor distribution on the arterial vasa recta in the outer and inner medulla, in addition to previously known sites in the glomeruli, renal arteries, renal pelvis, and medullary collecting tubules.
Identified preferential localization of glomerular binding sites to the foot processes of podocytes via electron microscopy.

Cite This Study

Koseki et al. (1986) studied this question.

synapsesocial.com/papers/6a7e66113565a0595cc76dbf https://doi.org/10.1254/jjp.42.27

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January 1, 1986The Japanese Journal of PharmacologyOpen Access

Intrarenal Localization of Receptors for α-Rat Atrial Natriuretic Polypeptide: An Autoradiographic Study with 125I-Labeled Ligand Injected in Vivo into the Rat Aorta

View Full Paper

Ask AI

Bookmark

Authors

CKChizuko KosekiTagCyx Biotechnologies (Japan)YKYasushi KanaiTohoku University YHYujiro HayashiOsaka Prefectural Medical Center

Discussion

Member takes

Overview

Refines rodent ANP receptor maps; extends prior localization data but leaves open human relevance.

Key Points

Determine the intrarenal distribution and specific cellular binding sites of alpha-rat atrial natriuretic polypeptide (alpha-rANP) receptors under in vivo conditions.
Injected [125I]-labeled alpha-rANP into the aorta of living rats under physiological conditions.
Mapped intrarenal binding sites using light microscopic and electron microscopic autoradiography across cortical and medullary structures.
Demonstrated prominent receptor distribution on the arterial vasa recta in the outer and inner medulla, in addition to previously known sites in the glomeruli, renal arteries, renal pelvis, and medullary collecting tubules.
Identified preferential localization of glomerular binding sites to the foot processes of podocytes via electron microscopy.

Cite This Study

Koseki et al. (1986) studied this question.

synapsesocial.com/papers/6a7e66113565a0595cc76dbf https://doi.org/10.1254/jjp.42.27

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