Key result
Intracoronary administration of 0.75 mg/kg rtPA over 15 minutes resulted in significantly greater coronary thrombolysis compared to administration over 45 minutes (P < 0.05).
Why the study?
Does a 15-minute administration of intracoronary rtPA improve coronary thrombolysis compared to a 45-minute administration in a canine model of coronary thrombosis?
Population
Canine model of coronary thrombosis induced by injection of radioactive blood clot via a catheter placed in…
Comparison
0.75 mg/kg of recombinant tissue plasminogen… vs 0.75 mg/kg of recombinant tissue plasminogen…
Design
Preclinical
Follow-up
45 minutes
Authors
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Should not change clinical rtPA protocols; hypothesis-generating for infusion rate optimization in coronary thrombosis.
Does a 15-minute administration of intracoronary rtPA improve coronary thrombolysis compared to a 45-minute administration in a canine model of coronary thrombosis?
p-value: p=< 0.05
A faster rate of intracoronary rtPA administration (15 minutes vs 45 minutes) significantly improves early thrombolytic efficacy in a canine model.
Prewitt et al. (1994) studied Coronary thrombosis. recombinant tissue plasminogen activator (rtPA) vs. 0.75 mg/kg rtPA over 45 minutes was evaluated on Extent of coronary thrombolysis by 30 and 45 minutes after onset of treatment (p=< 0.05). Intracoronary administration of 0.75 mg/kg rtPA over 15 minutes resulted in significantly greater coronary thrombolysis compared to administration over 45 minutes (P < 0.05).
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