Adducts 4 of Schiff bases and 3,4-dihydroisoquinolines with acyl chlorides react with Grignard reagents 5 in an intermolecular α-amidoalkylation reaction to the corresponding tertiary amides or 1-substituted 2-acyltetrahydroisoquinolines.
No takes yet. Share an insight, caveat, or question.
Venkov et al. (1995) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: