Key result
IGF-1 and myostatin antagonistically regulate muscle mass by balancing protein synthesis and growth inhibition.
This review highlights the opposing roles of the IGF-1 and myostatin signaling pathways in regulating muscle mass and hypertrophy.
Hypothesis-generating for muscle mass modulation; prospective trials needed before clinical adoption.
The control of muscle mass depends mainly on the action of two signaling pathways: IGF-1 axis and Myostatin.While one (IGF-1) signals increases in protein synthesis, the other (myostatin) acts by inhibiting muscle growth.The interaction of these signaling pathways with other mechanisms determines muscle mass.Furthermore, an important player in the process are the satellite cells in a dependente or non-dependent way to hypertrophy process.
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Marco Machado (2021) conducted a review in Muscle hypertrophy. IGF-1 and Myostatin pathways was evaluated. The control of muscle mass depends mainly on the antagonistic actions of the IGF-1 pathway, which signals protein synthesis, and myostatin, which inhibits muscle growth.
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