Association of Tricuspid Regurgitation With Mortality in Heart Failure With Left-Sided Heart Disease

Figure 1. Study Population (A) Flow chart of algorithm in phenotyping HF patients with left-sided heart disease. (B) TR grade in HF patients with left-sided heart disease. CIED = cardiac implantable electric device; EF = ejection fraction; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; LVD = left-sided valve dysfunction; TR = tricuspid regurgitation; TV = tricuspid valve; WET-HF = West Tokyo Heart Failure.

Figure 2. Cumulative Incidences of All-Cause Death From the Admission of the Index Hospitalization for Heart Failure (A) HF with LVD, (B) HF without LVD, and (C) HFpEF. Abbreviations as in Figure 1.

Figure 3. Cumulative Incidences of Rehospitalization for HF From the Discharge of the Index Hospitalization for Heart Failure (A) HF with LVD. (B) HF without LVD. (C) HFpEF. Abbreviations as in Figure 1.

Figure 4. Association of TR Across Phenotypes of Left-Sided Heart Disease (A) All-cause death and (B) rehospitalization for heart failure. Abbreviations as in Figure 1.

Figure 5. Cumulative Incidences of All-Cause Mortality in Patients With Left-Sided Valve Disease (A) Mitral regurgitation, (B) mitral stenosis, (C) aortic regurgitation, (D) aortic stenosis. LVEF = left ventricular ejection fraction; TR = tricuspid regurgitation.

Figure 6. Subgroup Analyses for Survival Effects of Tricuspid Regurgitation in Left-Sided Heart Disease AF = atrial fibrillation; CIED = cardiac implantable electric device; CKD = chronic kidney disease; EF = ejection fraction; HF = heart failure; PH = pulmonary hypertension.

Central Illustration. Tricuspid Regurgitation in Acute Decompensated Heart Failure With Left-Sided Heart Disease Patients with acute decompensated HF were classified based on the presence of LVD and cardiomyopathy, using data from the West Tokyo Heart Failure registries. LVD was defined as the presence of significant aortic and/or mitral valve disease graded as moderate or severe. HFpEF was classified by the absence of LVD, cardiomyopathy, or a lead crossing the tricuspid valve. HF = heart failure; HFpEF = heart failure with preserved ejection fraction; LVD = left-sided valve dysfunction; LVEF = left ventricular ejection fraction; TR = tricuspid regurgitation; TV = tricuspid valve.