What question did this study set out to answer?

To collate and evaluate adverse events associated with benzathine penicillin G administration for secondary prophylaxis of rheumatic heart disease.

June 1, 2019Heart AsiaOpen Access

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

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To collate and evaluate adverse events associated with benzathine penicillin G administration for secondary prophylaxis of rheumatic heart disease.
Conducted a literature review and created a case report questionnaire distributed across physician networks to retrospectively collect adverse event reports.
Assessed collected cases using the Brighton Collaboration case definition to determine whether events met criteria for anaphylaxis.
Gathered 10 case reports of patients ranging from early teens to adults, all of whom had clinical or echocardiographic evidence of valvular disease.
Most patients (80%) had previously received benzathine penicillin G without adverse reactions, and 8 of the 10 reported events were fatal.
Only 3 of the 10 cases met Level 1 Brighton Collaboration criteria consistent with anaphylaxis.

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Implication

Retrospective case series finds cardiac compromise rather than anaphylaxis drives fatal reactions to benzathine penicillin G in rheumatic heart disease, suggesting alternative mechanisms.

Cite This Study

Marantelli et al. (2019) studied this question.

synapsesocial.com/papers/6aa3a2ba971540f143c7f8df https://doi.org/10.1136/heartasia-2019-011191

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Implication

Retrospective case series finds cardiac compromise rather than anaphylaxis drives fatal reactions to benzathine penicillin G in rheumatic heart disease, suggesting alternative mechanisms.

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

Key Points

Discussion

Implication

Cite This Study

Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

Key Points

Discussion

Implication

Cite This Study

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