Multiple Myeloma: Report of a Case Showing Unusual Remission Lasting Two Years Following Severe Hepatitis

Case Reports1 July 1955MULTIPLE MYELOMA: REPORT OF A CASE SHOWING UNUSUAL REMISSION LASTING TWO YEARS FOLLOWING SEVERE HEPATITISROSE E. LONDON, M.D.ROSE E. LONDON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-1-191 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past 25 years multiple myeloma has been regarded with interest because of the increasing number of reported cases,1, 2, 3, 4 the curious associated abnormalities in protein metabolism, and the clinical trial of certain new drugs. In the growing literature accounts of spontaneous remission are rare, and effective therapy is lacking. Sporadic cases in which radioactive phosphorus,5 urethane,6 stilbamidine7 or adrenocorticotropic hormone8 have produced remissions for variable periods of time are exceptional.The following case of multiple myeloma is reported because of the spectacular and complete remission in the clinical and hematologic aspects of the disease for a...Bibliography1. BayrdHeck EDFJ: Multiple myeloma; a review of eighty-three proven cases, J. A. M. A. 133: 147, 1947. CrossrefMedlineGoogle Scholar2. Meacham G: Plasma cell myeloma, Ann. Int. Med. 38: 1035, 1953. LinkGoogle Scholar3. LichtensteinJaffe LHL: Multiple myeloma: a survey based on thirty-five cases, eighteen of which came to autopsy, Arch. Path. 44: 207, 1947. Google Scholar4. GeschickterCopeland CFMM: Multiple myeloma, Arch. Surg. 16: 807, 1928. CrossrefGoogle Scholar5. BayrdHall EDBE: Unusual remission after radiophosphorus therapy in a case of acute plasma cell leukemia, Blood 3: 1019, 1948. CrossrefMedlineGoogle Scholar6. Bayrd ED: Personal communication. Google Scholar7. RundlesDillonDillon RWMLES: Multiple myeloma. III. Effect of urethane on plasma cell growth, abnormal serum protein components, and Bence Jones proteinuria, J. Clin. Investigation 29: 1243, 1950. CrossrefMedlineGoogle Scholar8. SnapperTurnerMoscovitz ILHL: Multiple myeloma, 1953, Grune and Stratton, New York, p. 14. Google Scholar9. ThornForshamFrawleyHillRocheStahelinWilson GWPHRFSRMDDL: The clinical usefullness of ACTH and cortisone, New England J. Med. 242: 783, 1950. CrossrefMedlineGoogle Scholar10. KestersonMcSwain JB: Myeloma of bone, J. Bone and Joint Surg. 34: 224, 1952. CrossrefGoogle Scholar11. GarlandKennedy LHBR: Roentgen treatment of multiple myeloma, Radiology 50: 297, 1948. CrossrefMedlineGoogle Scholar12. DoljanskiRosin LA: Studies on the early changes in the livers of rats, treated with various toxic agents, with especial reference to the vascular lesions, Am. J. Path. 20: 945, 1944. MedlineGoogle Scholar13. MeachamTillotHeinle GFWRW: Liver damage after prolonged urethane therapy, Am. J. Clin. Path. 22: 22, 1952. CrossrefMedlineGoogle Scholar14. OhlerHoughtonMoloney RLJDWC: Urethane toxicity; report of a case of hepatic necrosis apparently due to urethane, New England J. Med. 243: 984, 1950. CrossrefMedlineGoogle Scholar15. NautsFowlerBogatko HCGAFH: A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man, Acta med. Scandinav. Suppl. 276: 5-9, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Miami Beach, Florida*Received for publication July 2, 1954.From the Departments of Medicine and Pathology, Mount Sinai Hospital of Greater Miami, Miami Beach, Florida. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byConclusionClinical development directions in oncolytic viral therapyOncolytic viral therapiesSelective Replicating Viral VectorsSelectively replicating viral vectorsOncolytic VirusesReplicating vectors for gene therapy of cancer: risks, limitations and prospectsFever, Pyrogens and CancerDIVISION OF MICROBIOLOGY: PRESENT STATUS OF ONCOLYTIC VIRUS STUDIES*Case 45261Dysproteinemia 1 July 1955Volume 43, Issue 1Page: 191-201KeywordsClinical trial reportingDrug metabolismDrugsHepatitis AHepatitis EHospital medicineLesionsMultiple myelomaProtein metabolismProteins ePublished: 1 December 2008 Issue Published: 1 July 1955 PDF downloadLoading ...