Surveillance study identifies new CPV-2a as the predominant circulating lineage in domestic dogs, indicating ongoing viral evolution and divergence from original vaccine strains.
The present study was aimed to characterize the circulating strains isolated from different districts of Andhra Pradesh by phylogenetic analysis and sequencing of the highly variable VP2 (viral protein) capsid protein gene of canine parvovirus (CPV).Phylogenetic analysis was done on randomly selected 18 PCR-positive samples from a collection of 342 faecal samples suspected of CPV.A commercially available canine parvovirus vaccine strain was also included in the study.Of the 19 samples sequenced, the vaccine was of CPV-2 and of the remaining 18 sequenced samples, 13 were new CPV-2a, 4 were new CPV-2b variants and one sample might be a further mutated variant of new CPV-2a.The CPV isolates were having 99.35 to 100% similarity with the CPV strains of other countries.The circulating strains also had a similarity of 99.99% to 100% with reference strains present in the GenBank.The phylogenetic analysis revealed that the virus strains formed a close ancestral relationship with the Indian and Chinese strains of CPV-2a and CPV-2b.It could be concluded that new CPV-2a was found to be the predominant strain circulating in Andhra Pradesh besides the presence of a few new CPV-2b and a further mutated variant of new CPV-2a at the adjacent borders of other states with Andhra Pradesh.
No takes yet. Share an insight, caveat, or question.
Kumari et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: