Key result
Low-carbohydrate diet undergoes evaluation versus low-fat diet for diabetic cardiomyopathy in an ongoing trial.
Why the study?
Diabetic cardiomyopathy often evolves to heart failure, and recommended low-fat diets have provided limited symptom relief.
Does a low-carbohydrate diet improve a composite of NYHA class, hospital admissions, thirst distress, and QoL in adult patients with diabetic cardiomyopathy compared to a low-fat diet?
RCT (n=80)
Randomized
No
Does a low-carbohydrate diet improve a composite of NYHA class, hospital admissions, thirst distress, and QoL in adult patients with diabetic cardiomyopathy compared to a low-fat diet?
This protocol describes a randomized controlled trial to evaluate the efficacy of a low-carbohydrate diet versus a low-fat diet for improving symptoms and quality of life in patients with diabetic cardiomyopathy.
Background: Insulin resistance (IR) and type 2 diabetes (T2DM) promote myocardial dysfunction in the absence of traditional cardiovascular risk factors such as hypertension or coronary heart disease. Termed diabetic cardiomyopathy (DMCM), this type of cardiomyopathy often evolves to heart failure (HF), therefore worsening outcomes for people living with T2DM. Low-fat diets (LF) have been recommended for patients with cardiovascular disease but have provided limited symptom relief.Aim: The aim of this research is to examine the effect of a low-carbohydrate (LC) diet compared with usual care (UC) in patients with DMCM. This study hypothesises that the LC diet will improve symptoms of HF and quality of life (QoL) in patients with DMCM.Setting: For this 16-week randomised controlled trial 80 adult patients ( 18 years of age) with T2DM (HbA1c ≥ 6.5) or IR (triglyceride glucose index value [TyG] 4.49) and HF from an outpatient HF clinic in Victoria, Australia were recruited.Methods: Participants will be randomised to a LC or a LF diet (UC) group. The primary outcome is a composite endpoint of changes in New York Heart Association (NYHA) class, hospital admissions, thirst distress and QoL. The secondary endpoint is a 2% change in HbA1c from baseline. Outcomes will be assessed at baseline, week 6 and week 16.Results: This article describes a protocol for a radomised controlled trial (RCT). The results of this trial will be published at the completion of the study.Conclusion: The results from this trial will provide an insight into the future dietary management of DMCM for both patients and healthcare practitioners.
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Kleissl-Muir et al. (2022) conducted an RCT in Diabetic cardiomyopathy (n=80). Low-carbohydrate diet vs. Low-fat diet (usual care) was evaluated on Composite endpoint of changes in New York Heart Association (NYHA) class, hospital admissions, thirst distress and QoL. A low-carbohydrate diet is being evaluated against a low-fat diet for diabetic cardiomyopathy in an 80-patient, 16-week randomized controlled trial protocol, with results pending.
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