Key result
Active multifactor primary prevention linked to ~37% lower CV mortality in high-risk men.
Why the study?
Does multifactor primary prevention reduce cardiovascular mortality in middle-aged men without initial ischemic heart disease?
Population
5,680 men aged 40-59 years without initial clinical signs of ischemic heart disease (IHD)
Comparison
Active correction of IHD risk factors for 5 years vs Comparison group without active preventive…
Design
Cohort
Follow-up
10 years
Authors
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May support multifactor prevention in high-risk men; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=5,680)
Does multifactor primary prevention reduce cardiovascular mortality in middle-aged men without initial ischemic heart disease?
Active multifactor primary prevention significantly reduces long-term cardiovascular mortality in middle-aged men, particularly those at high or very high baseline risk.
A. M. Kalinina (2014) conducted a cohort in Ischemic heart disease (n=5,680). Active correction of ischemic heart disease risk factors (high blood pressure, hypercholesterolemia, overweight, smoking, low physical activity) vs. No active preventive measures was evaluated on Cardiovascular death. Active multifactor primary prevention reduced the risk of cardiovascular death by 36.9% in men with initially high risk and by 43.4% in men with initially very high risk.
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